• Workpackage1
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• Workpackage 5
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• Workpackage 8

WP5:characterisation of the back-up anti-HCV MAb

The goal of this work package will be to characterise in depth the back-up anti-HCV MAb by

• Assessing the capacity of the back-up anti-HCV MAb to neutralise pseudotype viruses (HCVpp) representing diverse HCV genotypes

• Assessing the capacity of the back-up anti-HCV MAb to neutralize infectioous clones of HCV (HCVcc)

• Evaluating the E1E2-binding affinity of the back-up anti-HCV MAb

• Mapping the E1E2-epitope(s) recognized by the back-up anti-HCV MAb

• Sequencing the variable regions of the heavy and light chains of the back-up anti-HCV MAb

• Determine the in vitro and in vivo neutralizing activity of the humanised antibody